Ultra long-term EEG (EpiOs)
Chronic EEG, in partnership with Wyss Center
Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. Individual patients can suffer variable frequency of seizures, but are not necessarily aware of their own seizures that can occur during sleep, or lead to amnesia. A device that could chronically track seizures and give an objective count would enable a novel personalized approach to the problem. The EpiOs projects consist of the development and clinical trial of a sub-scalp EEG that is inserted between the scalp and the skull via minimally invasive surgical technique.
Transcranial Alternating Current Stimulation (tACS)
In partnership with Pulvinar Neuro
Non-invasive brain stimulation has emerged as a promising scientific tool to modulate brain activity in a targeted way. In collaboration with Pulvinar Neuro, we are studying new paradigms for treating illnesses of the central nervous system with transcranial alternating current stimulation (tACS). Pulvinar Neuro is a US-based start up company with the mission of providing the next generation neurotechnology for recording and modulating brain activity. This exciting collaboration is based on integration of target identification, engagement, and validation through innovative neuroscience and translational research that is enabled by the unique capabilities of the NeuroTec.
Brain-inspired Computing for EEG analysis
In partnership with ETHZ
Mobile (ultra-)long-term recordings of electrical brain activity (EEG) yield extremely large amounts of data, which may cause significant bottlenecks for transmission to a digital cloud for further analysis. Therefore novel approaches aim to solve this problem by processing the data as close as possible to the sensors. However, processing data close – or even in – the sensors depends on very energy-efficient methods to enable small form-factor and long-life operation. Highly energy-efficient algorithms are developed in the modern field of brain-inspired hyperdimensional computing. In this project hyperdimensional computing is exploited for efficient analysis of (intracranial) EEG (http://ieeg-swez.ethz.ch/)
In partnership with ETHZ
Sleep plays a fundamental role in health and well-being. Bad sleep hygiene, sleep deprivation, and sleep disorders increase risk of cardiovascular diseases and have a negative impact on mood, cognitive performance, and motor function. The vision of the Somnomat project is the development of an autonomous robotic platform, able to monitor the user during sleep and to interact with him to improve sleep quality.
NeuroStimulation started in the 1990s for Parkinson disease, but is still in its infancy regarding the understanding of its impact on brain physiology. This lack of understanding prevents physician to use the right set of stimulation parameters for the right patient. One promising approach is to use a closed-loop to sense brain activity, stimulate and sense again to evaluate the impact of the stimulation. This approach will be used for stimulation of deep and cortical structures for treatment of movement disorders, epilepsy and psychiatric disorders.